Benefits. The MRI rating had been significantly associated on the torque coefficient (3rd r = 2.Fifty seven) along with the temporalis (ur Equates to 2.80) along with masseter (r Is equal to Zero.Fouthy-six) muscle tissue standardized evenness. Your discerning potential involving participant age along with sEMG scores inside distancing the 2 groups had been assessed through receiver working trait evaluation. Every one of the sEMG scores revealed a substantial potential within discriminating in between osteoarthrosis as well as drive displacement. Results. Film of the masticatory muscle mass perform by means of sEMG is usually a 1st analysis method of patients with TMDs, making your reservation for MRI examination to be able to selected cases.”"The most promising along with rep earlywood vessel guidelines ended up discovered for dendroecological applications in maple. Current changes of the way found in tree-ring and quantitative solid wood Selleck LOXO-101 physiological studies have made it easier for in order to broaden the selection of parameters that contain enviromentally friendly info. In today’s review, all of us determined probably the most offering parameters regarding signal strength, representativeness, along with applicability within pine (Quercus robur M.) coming from a couple of web sites throughout Germany with different wetness plans. Many of us examined about three tree-ring as well as 16 boat variables. Major component investigation was utilized to detect groups associated with fairly similar parameters. Correlation examination as well as established dendrochronological techniques were utilised to select the most robust variables. In the 16 original physiological guidelines, half a dozen turned out to be ideal for tree-ring bodily reports according to the screening conditions. They were indicate area of the ships of the very first row, mean with the 5 biggest ships, overall charter boat area, complete portion of the vessels taking out the first row, charter boat occurrence, along with total boat area as being a percentage of tree-ring region. These kind of parameters were used on Bafilomycin A1 nmr trials to find buy CBL0137 lagged replies to be able to bad and the good tip many years utilizing superposed epoch analysis. Unfavorable, we.elizabeth., dried up, suggestion a long time provoked absolutely no lagged changes in assessed variables with sometimes web site; whilst beneficial, i.at the., wet, tip years revealed a lagged negative reply of variables, that was much more distinct in the less damp web site.In .”Recent technological as well as visual advances in fat analysis have provided people a glimpse into the correct adaptability of the lipidome and the complexness of lipid signaling varieties. Progress the same throughout protein hormones and genetic makeup provides shown all of us together with fresh indication walkways and molecular elements for that fat steps. G-protein-coupled receptors (GPCR) appear to participate in a main part from the damaging many lipid alerts and are also by themselves goals for some of these.}
The actual ordered framework of the design furthermore enables quickly adjusting the particular list of equations conveying restenosis progression to boost product trustworthiness and making use of your heavy knowledge of biological elements managing the diverse stages of clean muscle tissue cellular progress as well as growth. Additionally, because of the straightforwardness and also to the lower program specifications as well as computer (Processor) time, each of our product enables receiving quick sights regarding technique habits.Inches”Systemic lupus erythematosus (SLE) is really a persistent auto-immune disease associated with not known etiology with multisystem effort. A number of lung difficulties which includes pleuritis, pneumonitis, transmittable pneumonia, as well as lung lose blood, have been described in patients with SLE. Pulmonary lose blood can be a major life-threatening manifestation in children and also teenagers using SLE. Mycophenolate mofetil is an immunosuppressive adviser employed in strong wood transplantation, and it will participate in an escalating position throughout auto-immune illness. On this report, we all existing a couple of instances of child years SLE together with recurrent lung hemorrhage, which were less competent to be able to treatment using high-dose adrenal cortical steroids, cytotoxic therapy, IVIG, plasmaphoresis, and loyal treatments, yet taken care of immediately β-Nicotinamide nmr Four mycophenolate mofetil. The multimodal remedy which include mycophenolate mofetil had been efficient at treating those two children.In .”Phytochemical exploration with the dichloromethane extract of the simply leaves involving Peltophorum pterocarpum, an exotic decorative sapling, triggered the particular solitude associated with 12 ingredients (1-12). One particular fresh derivative regarding peltogynoid ophioglonin (One particular) along with a fresh 2-phenoxychromone (A couple of) using its 3′-O-beta-D-glucoside kind (3) are described here for the 1st time. Moreover, seven flavonoid types, which include peltogynoid ophioglonin (Several), were isolated for the first time from this grow. Your constructions had been driven by spectroscopic and chemical substance approaches. Evaluation of the actual estrogenic routines of merely one, 2, along with Several using diverse product cell programs revealed that Some ended up being estrogenic which Only two was largely non-active. Curiously check details , One particular was struggling to activate the actual growth of breasts and also endometrial most cancers tissues but shown significant excess estrogen receptor alpha-mediated activation regarding gene appearance. This specific statement suggests that One could be additional looked at due to the cancer chemopreventive potential.In .”Today, the use (which we are able to state ‘return in order to nature’) associated with classic herbal medicines, plant based well being Selisistat order items, pharmaceutical drugs foodstuff health supplement, makeup, and so forth. is growing because of the developing recognition that normal items are safe and sound; possess sometimes absolutely no as well as flexible unwanted side effects. The goal of this research ended up being to check out immunomodulatory qualities of 5 diverse healing plant life employed in American indian program regarding drugs for the Wistar test subjects.}
These types of outcomes weren’t noticeable throughout younger (5-9 weeks of age) mice. Cultural housing (3-5 hamsters/cage) eliminated the consequences 4-Hydroxytamoxifen nmr of circadian arrhythmia in emotionality. Circadian arrhythmia alone was lacking impact on hippocampal as well as cortical interleukin-1 beta (IL-1 ‘beta’) and indoleamine 2,3-dioxygenase (Ido) mRNA phrase in older mice, nevertheless cultural homes reduced hippocampal IL-1 ‘beta’ and also Ido mRNAs. The data show circadian interruption could in a negative way affect effective state, understanding that this particular effect will be distinct in old folks. Although clear interactions involving circadian arrhythmia as well as constitutive limbic proinflammatory exercise just weren’t evident, the current files claim that cultural real estate significantly inhibits constitutive hippocampal r along with Ido task, which may help with the ameliorating connection between social real estate on a quantity of mental behaviors. (C) 2014 Elsevier W./. Almost all legal rights set aside.In .”Studies of problems pursuing reconstructive surgery using improvements amid girls together with cancers of the breast are expected. Because the, to expertise selleck , first future long-term review many of us examined the existence of problems subsequent delayed chest reconstruction separately pertaining to one-and two-stage procedures. In the Danish Personal computer registry pertaining to Plastic cosmetic surgery with the Breasts, that has prospectively listed data for females undergoing busts implantations considering that 1999, many of us discovered 559 girls without a history of radiotherapy undergoing 592 postponed busts reconstructions subsequent breast cancers during the period 2000 to be able to 2007; 239 one-stage procedures along with 353 two-stage methods. The particular postoperative program via Late 09 has been examined by cumulative incidence modifying for rivalling risks for your selected benefits; hematoma, infection, seroma, implant break, severe capsular contracture (changed Baker Three as well as Intravenous), extrusion of the enhancement, asymmetry/displacement from the implant, any kind of side-effect, as well as reoperation. These types of analyses ended up carried out equally total as well as on their own according to sort of procedure (one-or two-stage). The entire 10-year danger estimations were Sixty eight.1% for just about any complications, Seven.7% pertaining to significant capsular contracture, 33.3% for displacement/asymmetry of the augmentation along with Thirty-eight.6% for reoperation. When comparing one- and two-stage processes, many of us noticed substantially higher risk quotations pertaining to an infection, seroma and also extrusion with the enhancement pursuing two-stage methods, whereas the chance of reoperation ended up being significantly higher following a one-stage method. Both for methods, virtually all reoperations were due to asymmetry as well as displacement from the augmentation.\n\nIn finish, non-radiated one- as well as two-stage postponed chest embed reconstructions tend to be connected with considerable risks of issues and reoperation which should be considered in the organizing associated with breasts recouvrement. (d) Next year Uk Affiliation involving Plastic HTS assay , Rebuilding and Artistic Cosmetic surgeons.}
In .”Early research discovering supplement Deborah being an antirachitic element resulted in scientific studies within vitamin and mineral D-deficient mixers triggered an elementary idea of your system regarding activity involving vitamin and mineral Deb. Recent reports employing genetically revised rats have given important new clues about the particular bodily function associated with nutritional Deb from goal flesh and also the practical great need of nutritional N focus on protein, along with the functional great need of meats active in the transfer and also metabolic process regarding vitamin and mineral Linsitinib mouse N. Scientific studies with such rodents get played an ever more part in elucidating your mechanisms mixed up in control over calcium mineral homeostasis and possess supplied facts to get a role involving vitamin D in extraskeletal wellness.Inches”With once a year new case recognition regarding Four thousand men and women, a Rank Only two impairment fee associated with 12%, along with virtually 10% little one rate amid fresh instances, leprosy stays a disease regarding community well being relevance throughout Africa. Faced with view of reduced endemicity; a heading downward monetary allocation for you to leprosy management; and a pervasive decrease of know-how; it is crucial with regard to Africa in order to re-organise the leprosy management solutions to increase decrease the stress of the ailment and make sure top quality care to people impacted by leprosy.In .”OBJECTIVE: The goal of your research ended up being to read the connection involving earlier miscarriages and also the perils associated with placental problems issues, such as preeclampsia, stillbirth, start of an little regarding gestational age group (SGA) baby, placental abruption, along with spontaneous preterm birth. STUDY DESIGN: Within a population-based cohort review which include 619,587 primiparous females, many of us projected risks of placental dysfunction disorders for women together with One particular (in Equals 68,185), 2 (d Is equal to 11,410) and three or maybe more (and = 3823) self-reported previous JAK inhibitors in development miscarriages. Hazards were computed since odds Selleckchem BVD-523 rates by unconditional logistic regression investigation along with changes were created for maternal grow older, earlier maternity body mass index, elevation, smoking cigarettes routines, region of delivery, numerous years of official schooling, in vitro fertilization, long-term high blood pressure levels, pregestational diabetes, thyrois issues, endemic lupus erythematosis, baby sexual intercourse, as well as 12 months associated with giving birth. Final results: Weighed against women without any previous miscarriage, women along with One preceding miscarriage got almost no greater hazards. Ladies along with Only two earlier miscarriages experienced improved perils associated with natural preterm start, preterm ( smaller than 37 months) SGA child, along with placental abruption. The actual costs of ailments had been larger for ladies along with Three or maybe more earlier miscarriages weighed against females without having previous miscarriages: preeclampsia, Your five.83% as opposed to Four.27%; stillbirth, 2.69% as opposed to 3.33%, SGA toddler, Five.}
4 to 33.0. The addition of HUMCS at a low additive amount reduced the peak heat-release rate, total heat release, and heat-release capacity obviously. Furthermore, scanning electron micrographs of char residues revealed that HUMCS could prevent the IFR-PP composites from forming a dense and compact multicell char, which could effectively protect the substrate material from combusting. (C) 2014 Wiley Periodicals, Inc.”
“Background: Patients with rheumatoid arthritis (RA) may have selleck screening library more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis
prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA. Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive BBI608 protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences
in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses. Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis
severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs. Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.”
“The fate of trace selleck products elements in soils, sediments, and surface waters is largely determined by their binding to reactive components, of which organic matter, metal oxides, and clays are considered most important. Assemblage models, combining separate mechanistic complexation models for each of the reactive components, can be used to predict the solid-solution partitioning and speciation of trace elements in natural environments. In the present review, the authors provide a short overview of advanced ion-binding models for organic matter and oxides and of their application to artificial and natural assemblages.
However, no analytical model is hitherto available to jointly optimize the price discount for the promoted product
and the product portfolio to recommend. This paper provides a probability model to complete the task. The proposed model motivates customers through an attractive price discount for the promoted product, while simultaneously encouraging customers to purchase the non-discounted products through the recommendation system. The numerical studies show that the proposed method attains Raf inhibitor higher profits than do conventional methods. Finally, we offer ACY-738 purchase managerial insights and provide useful guidelines to help e-tailers to make the most profitable online promotional decisions.”
“Objective: To analyze the results of multiple measurements of resonance frequency analysis (RFA) repeated in patients implanted with Cochlear Baha (R) BI300 implants to look for trends, which potentially might serve as indicators of successful osseointegration. Patients:
Forty-five patients implanted with the BI300 implants at the Department of Otolaryngology, Poznan University of Medical Sciences; consecutive values were available for 14 of these 45 patients. Intervention(s): Evaluation Mdm2 inhibitor of the implant stability through resonance frequency analysis; 4 to 10 measurements in each patient were performed during the surgery and after 1 week and 1 month. Main Outcome Measure(s): Attention was focused on the results of RFA, defined as the differences between recorded marginal values of the implant stability quotient (ISQ): the average-ISQ value [(maximal ISQ value + minimal ISQ value)/2]
and delta-ISQ (maximal ISQ value – minimal ISQ value). Results: The average-ISQ value increased from 58.43 at the time of implant placement to 61.89 at the end of the observation period, with a minimum recorded value of 56 and a maximum of 64.5. Delta-ISQ showed a maximal drop from 3.86 at the time of surgery to 1.93 after 1 month. Significant differences were observed between surgery and a month later but also between 1 week and 1 month after surgery. Conclusion: Our data demonstrate that differences between recorded stabilities of the implant in different planes based on ISQ values tend to decrease over time, indicating that the implant acquires symmetrical stability, which may reflect the good quality of the bone-implant interface.
\n\nDesign.\n\nBetween-method qualitative and quantitative triangulation was used. Semi-structured interviews were conducted and transcribed data were analysed by critical thematic analysis.\n\nResults.\n\nTwenty women in Taiwan, > 65 years old, (mean = 72 center dot 95) were interviewed within three years of being widowed. There were two informant groups: DZNeP those with intrinsic religious beliefs and those with extrinsic religious beliefs. They all reported intrapersonal and interpersonal problems. Several major coping strategies arose: ‘practising positive or negative attitudes for adaptation’; ‘using person-focused
actions’; and ‘taking the initiative or passively seeking help from others or helping others’. Informants with intrinsic religious beliefs reported fewer coping problems by holding positive attitudes and
taking multiple actions for adaptation. The extrinsic check details religious group had more negative adaptation attitudes, such as withdrawal and low self-esteem and practised less faith religious activities in worshipping ancestors, experiencing fatalism and using divination. They reported more coping problems than the intrinsic religious group.\n\nConclusion.\n\nWidows in Taiwan have different coping problems and strategies in postbereavement adjustment, affected by their different religious beliefs systems. More research is required to establish the generalisabilty of these findings.\n\nRelevance to clinical practice.\n\nWidows in Taiwan need to be assessed for their religious belief TPCA-1 mw systems and how this affects their ability to cope during bereavement. Clinicians should actively provide grief support and encourage new methods of social adaptation, especially with widows with extrinsic religious beliefs who may have less self-esteem and negative adaptation behaviours.”
“BACKGROUND: Yellowmargined leaf beetle, Microtheca ochroloma, is the most damaging pest of organic crucifer crops in the southern United States. Experiments were conducted over four growing seasons (20072010) in Alabama to evaluate some botanical
and microbial insecticides approved by the Organic Materials Review Institute (OMRI) against M. ochroloma in organically grown crucifer crops. Insecticides evaluated included PyGanic (R) (pyrethrum), Aza-Direct (R) (azadiractin), Entrust (R) (spinosad), Mycotrol O (R) (Beauveria bassiana strain GHA) and NOFLY (R) [Isaria ( = Paecilomyces) fumosoroseus strain FE 9901]. Two experimental organic formulations, Tick-Ex (Metarhizium anisopliae strain F52) and MBI-203 (Chromobacterium subtsugae), and one non-OMRI-listed formulation, Novodor (R) (Bacillus thuringiensis subspecies tenebrionis), were also evaluated. The insecticides were applied as stand-alone treatments at recommended field rates on a weekly schedule.
“Maximum likelihood and Bayesian inference analyses of nuclear ribosomal DNA (ETS1f) and plastid DNA (rpl32-trnL, trnH-psbA) sequence data are presented for C4 Cyperus’ (Cyperaceae). The term C4 Cyperus’ encompasses all species of Cyperus s.l. Duvelisib mouse that use C4 photosynthesis linked with chlorocyperoid vegetative anatomy. Sampling comprises 107 specimens of 104 different taxa, including many
of the subdivisions of C4 Cyperus s.s. and all C4 segregate genera (Alinula, Ascolepis, Kyllinga, Lipocarpha, Pycreus, Queenslandiella, Remirea, Sphaerocyperus and Volkiella). According to our results, C4 Cyperus is a well-supported monophyletic clade nested in C3 Cyperus. Despite the lack of resolution along the backbone of the C4 Cyperus clade and for some internal branches, several well-supported clades can be distinguished. The first clade in C4 Cyperus is formed by Cyperus cuspidatus and C.waterloti. Other recognizable and well-supported clades correspond to segregate genera, i.e. Ascolepis, Lipocarpha including Volkiella, and Kyllinga. Species of C4 Cyperus s.s. form a core grade in which the C4 segregate genera are embedded. Pycreus, the largest segregate genus composed
of c. 120 species, is not monophyletic as it includes several C4 species of Cyperus s.s. This study establishes a phylogenetic framework INCB028050 molecular weight for revising the classification and character evolution in Cyperus s.l.(c) 2013 The Linnean Society of London”
“To determine effects of school breaks on influenza virus
transmission in the Southern Hemisphere, we analyzed 2004-2010 influenza-like illness surveillance data from Chile. Winter breaks were significantly associated with a two-thirds temporary incidence reduction among schoolchildren, which supports use of school closure to temporarily reduce illness, especially among schoolchildren, in the Southern Hemisphere.”
“Objective: To assess the prevalence and determinants of haematinic deficiency (lack of B12 folate or iron) and macrocytosis in blood from a national population-based https://www.selleckchem.com/products/ABT-263.html study of middle-aged and older adults. Methods: A cross-sectional study involving 1,207 adults aged bigger than = 45 years, recruited from a sub-study of the Irish National Survey of Lifestyle Attitudes and Nutrition (SLAN 2007). Participants completed a health and lifestyle questionnaire and a standard food frequency questionnaire. Non-fasting blood samples were obtained for measurement of full blood count and expert morphological assessment, serum ferritin, soluble transferrin receptor assay (sTfR), B12, folate and coeliac antibodies. Blood samples were also assayed for thyroid function (T4, TSH), liver function, aminotransferase (AST) and gamma-glutamyl transferase (GGT). Results: The overall prevalence (95% C. I.) of anaemia (Hb smaller than 13.5g/dl men and 11.3 g/dl women) was 4.6% (2.9%-6.4%) in men and 1.0% (0.2%-1.9%) in women. Iron deficiency (ferritin smaller than 17ng/ml men and smaller than 11ng/ml in women) was detected in 6.
We performed whole-cell recording from ELp neurons in a whole-brain preparation and examined the relationship between intrinsic excitability and IPI tuning. We found that spike frequency adaptation of ELp neurons was highly variable. Postsynaptic potentials (PSPs) of strongly adapting (phasic) neurons were more sharply tuned to IPIs than weakly adapting (tonic) neurons. Further, the synaptic filtering of IPIs by tonic neurons was more faithfully converted into variation in spiking see more output, particularly at short IP1s. Pharmacological manipulation
under current- and voltage-clamp revealed that tonic firing is mediated by a fast, large-conductance Ca2+-activated K+ (K-ca) current (BK) that speeds up action potential repolarization. These results suggest that BK currents Bioactive Compound Library high throughput can shape the temporal filtering of sensory inputs by modifying both synaptic responses and PSP-to-spike conversion. Slow SK-type K-ca currents have previously been implicated in temporal processing. Thus, both fast
and slow K-ca currents can fine-tune temporal selectivity.”
“To search for novel potent antitumor agent, a series of thiocolchicine derivatives (7a-i) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by spectral analysis. Their cytotoxicity against four human cancer cell lines (A2780, A549, BEL7402, and MCF7) in vitro were evaluated by MTT assay. The results indicated that many of the derivatives showed significant GDC-0973 in vivo anticancer activities, particularly, compounds 7h and 7i showed more potent cytotoxic activities of all screened cancer cells than colchicine and thiocolchicine.”
“Docetaxel is a taxane family antineoplastic agent widely employed in cancer chemotherapy. We developed
a liquid chromatography/tandem mass spectrometry method for the determination of docetaxel in human plasma. Plasma samples were deproteinized by acetonitrile containing internal standard paclitaxel. Chromatographic separation was performed on a TSKgel ODS-100V 3 mu m (50 mm x 2.0 mm i.d.) column using a mobile phase composed of acetonitrile-methanol-water-formic acid (50:5:45:0.1, v/v/v/v). Detection was performed on a triple-quadrupole tandem mass spectrometer with multi pie reaction monitoring (MRM) mode via electrospray ionization (ESI) source. This method covered a linearity range of 5-5000 ng/mL with the lower limit of quantification of 5 ng/mL. The intra-day precision and inter-day precision (R.S.D.) of analysis were less than 6.7%, and the accuracy (R.E.) was within +/- 9.0% at the concentrations of 5, 20, 200, and 2000 ng/mL. The total run time was 5.0 min. This method was successfully applied for clinical pharmacokinetic investigation. (C) 2012 Elsevier B.V. All rights reserved.”
“This study was conducted to determine the effects of various time lengths of restricted feeding at 0.
This tremendous effort of the scientific community has confirmed the view that cancer actually represents a wide variety of diseases originating from different organs. AZD8931 research buy These studies showed that TP53 and PI3KCA are the two most mutated genes in all types of cancers and that 30-70% of all solid tumors harbor
potentially ‘actionable’ mutations that can be exploited for patient stratification or treatment optimization. Translation of this huge oncogenomic data set to clinical application in personalized medicine programs is now the main challenge for the future. The gap between our basic knowledge and clinical application is still wide. Closing the gap will require translational personalized trials, which may initiate a radical change in our routine clinical practice in oncology.”
“Surgical Plethysmographic Index (SPI), calculated from pulse photo-plethysmographic amplitude oscillations, has been proposed as a tool to measure nociception anti-nociception balance during general anesthesia, but it is affected by several confounding factor that alter the autonomic nervous system (ANS) modulation. We hypothesized that SPI may be mainly affected by sympathetic stimulation independently from nociception. We studied the effects of two sympathetic stimuli on SPI, delivered
through passive head-up tilt at DMH1 chemical structure 45 and 90 degrees angles, in nine awake healthy adults. The sympathetic modulation was assessed by means of heart rate variability (HRV) analysis. Mean (SD) SPI significantly increased from baseline to 45 degrees [from 38.6 (13.7) to 60.8 (7.6), p smaller than 0.001)] and to 90 degrees angle tilt [82.3 (5.4), p smaller than 0.001]. The electrocardiographic mean R-to-R interval significantly shortened during both passive tilts, whereas systolic arterial pressure did not change during the study protocol. HRV changed significantly during the study protocol towards a predominance of
sympathetic modulation during passive tilt. Gravitational sympathetic stimulation at two increasing angles, in absence of any painful stimuli, affects SPI in awake healthy volunteers. AZD6094 SPI seems to reflect the sympathetic outflow directed to peripheral vessels.”
“Histone-like proteins (such as HU, H-NS, and Fis) participate in nucleoid organization and in DNA replication, recombination, and transcription. Cold shock and anoxia upregulates a homologue of HU (Hlp) in Mycobacterium smegmatis, the nonpathogenic model of Mycobacterium tuberculosis. We show using electrophoretic mobility shift assays that Hlp, which in addition to the HU fold has a basic C-terminal tail containing multiple PAKK and PAAK repeats, has very high affinity for DNA. The affinity of Hlp for 76 bp linear DNA is higher, K(d) = 0.037 +/- 0.001 nM, compared to art Hlp variant without the C-terminal repeats, K(d) = 2.5 +/- 0.